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N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- In Vitro (laboratory Use)
01
Overview
**N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide** (commonly known as W-7) is a synthetic small molecule that acts as a calmodulin antagonist. It features a naphthalene sulfonamide core with a chloro substituent at the 5-position and an aminohexyl side chain. W-7 binds to calmodulin, inhibiting its calcium-dependent activation of various enzymes and proteins, including calcium/calmodulin-dependent protein kinases. This compound is widely used in biochemical research to study calmodulin-mediated signaling pathways and the role of calcium in cellular processes[2][4][8]. It is not approved for clinical use but serves as an important tool compound in laboratory settings.
- Other names
- N-(6-aminohexyl)-5-chloronaphthalene-1-sulfonamide1-naphthalenesulfonamide, N-(6-aminohexyl)-5-chloro-65595-90-6
02
Targets
CaM (Calmodulin)
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