n-2-fluorenylacetamide

N-2-fluorenylacetamide, also known as 2-acetylaminofluorene (2-AAF), is a polycyclic aromatic compound historically studied for its profound carcinogenic and mutagenic properties[2][5][6]. This small molecule is used primarily in laboratory research as a model genotoxic carcinogen to induce liver cancer (hepatocarcinogenesis) and other tumors in animal models, notably rodents[2][5]. Its mechanism of action involves metabolic activation by cytochrome P450 enzymes (notably CYP1A2) to form N-hydroxy-2-AAF and other reactive intermediates, which produce DNA adducts leading to mutagenesis and carcinogenesis[5]. It is not used clinically and is handled only for research as a positive control in carcinogenicity studies or mechanistic toxicology[2][5].

Other names

2-acetamidofluorene2-acetylaminofluoreneN-(2-fluorenyl)acetamideN-2-fluorenylacetamideN2-fluorenylacetamideN 2-fluorenylacetamide2-fluorenylacetamide