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n-3-oxo-octanoyl-thiohomoserine lactone
- Development stage
- Preclinical
- Lead developer
- OMM Scientific
- Modality
- Small Molecules
01
Overview
n-3-oxo-octanoyl-thiohomoserine lactone is a small molecule analog of the bacterial signaling molecule N-3-oxo-octanoyl-homoserine lactone (3-oxo-C8-HSL). Developed by OMM Scientific, it is designed to interact with the AI-1 (Autoinducer-1) quorum sensing pathway, a communication system used by bacteria to coordinate gene expression based on population density. By mimicking or competing with natural acyl-homoserine lactones (AHLs), this thio-analog serves as a research tool to investigate quorum sensing mechanisms and explore potential anti-infective strategies that disrupt bacterial virulence. It is currently provided as a preclinical research reagent for the study of AI-1-type quorum sensing systems.
- Other names
- N-3-oxo-octanoyl-homoserine lactone analogN3-oxo-octanoyl-homoserine lactone analogN 3-oxo-octanoyl-homoserine lactone analog3-oxo-C8-thio-HSLN-(3-oxooctanoyl)-L-thiohomoserine lactone
02
Targets
LuxR (LuxR-type quorum sensing transcriptional regulator)LuxN (LuxN-type histidine kinase autoinducer-1 sensor)
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