n-acetyl-aspartyl-glutamate

N-acetyl-aspartyl-glutamate (NAAGA), also known as spaglumic acid, is a peptide-based small molecule mast cell stabilizer developed by Laboratoires Théa. It is primarily used for the treatment of allergic eye conditions, including vernal keratoconjunctivitis (VKC) and allergic conjunctivitis. NAAGA exerts its therapeutic effects through multiple anti-inflammatory pathways: it inhibits mast cell degranulation, modulates complement activation, reduces the production of inflammatory mediators like leukotrienes, and decreases the expression of eosinophil surface-adhesion molecules. The formulation "Naaxia Sine" is a preservative-free ophthalmic solution delivered via the ABAK multidose system to minimize ocular surface irritation and is often compared to other antihistamines or mast cell stabilizers in clinical settings.

Brand names

Naaxia SineNaaxia

Other names

NAAGAspaglumic acidN-acetyl-aspartyl-glutamic acidmagnesium spaglumatesodium spaglumate