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N-Desethyl Sunitinib
- Development stage
- Unknown
- Lead developer
- Pfizer
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
N-Desethyl Sunitinib (SU-012662) is an active metabolite of the small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor Sunitinib. It is formed from Sunitinib through metabolism by the cytochrome P450 3A4 (CYP3A4) enzyme. N-Desethyl Sunitinib is pharmacologically active and exhibits similar inhibitory activity to its parent compound, Sunitinib. Sunitinib, developed by Pfizer, targets various RTKs including vascular endothelial growth factor receptors (VEGFRs), platelet-derived growth factor receptors (PDGFRs), and KIT, thereby inhibiting tumor angiogenesis and proliferation.
- Other names
- Sunitinib Metabolite
02
Targets
PDGFRA (Platelet-derived growth factor receptor alpha)KIT (c-KIT proto-oncogene receptor tyrosine kinase)VEGFR2 (Vascular endothelial growth factor receptor 2)PDGFRB (Platelet-derived growth factor receptor beta)VEGFR-1 (Vascular endothelial growth factor receptor 1)VEGFR3 (Vascular endothelial growth factor receptor 3)CSF1R (Macrophage colony-stimulating factor receptor)RET (Rearranged during transfection receptor tyrosine kinase)FLT3 (Fms related receptor tyrosine kinase 3)
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