N-ethyl toluene-4-sulphonamide

N-ethyl toluene-4-sulphonamide is a small molecule sulfonamide derivative investigated for its potential as an antineoplastic agent. Preclinical research has demonstrated its cytotoxic activity against various human cancer cell lines, including HeLa (cervical cancer), MDA-MB231, and MCF-7 (breast cancer). The compound's mechanism of action involves direct interaction with DNA, specifically binding within the minor groove, which disrupts DNA function and leads to cell death. In comparative studies, it is often evaluated alongside other sulfonamide moieties to identify structural features that enhance anticancer efficacy and DNA-binding affinity.

Other names

N-ethyl-p-toluenesulfonamideN-ethyl-4-methylbenzenesulfonamideN-ethyl4-methylbenzenesulfonamideN-ethyl 4-methylbenzenesulfonamideETSAN-Ethyl-4-toluenesulfonamideN-Ethyl4-toluenesulfonamideN-Ethyl 4-toluenesulfonamide