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N-ETSD

Development stage: Discontinued
Modality: DNA Vaccines → Plasmid DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Prophylactic Vaccines → Vaccines & Immunotherapeutics, Recombinant Proteins and Enzymes
Administration: Subcutaneous, Sublingual, Oral, Intranasal

Overview

N-ETSD is a modified SARS-CoV-2 nucleocapsid (N) protein antigen, specifically an Enhanced T-cell Stimulation Domain. It is designed to enhance T-cell stimulation by directing the N antigen to the endosomal/lysosomal compartment, thereby increasing its potential for presentation via MHC class I and II pathways. N-ETSD is a key component of a dual-antigen COVID-19 vaccine, hAd5-S-Fusion+N-ETSD, which utilizes a human adenovirus serotype 5 platform to deliver both the modified N protein and a modified spike (S-Fusion) protein to elicit robust cellular immune responses.

Other names: Enhanced T-cell Stimulation Domain (N-ETSD)N antigen modified with an Enhanced T-cell Stimulation Domain

Targets

MHC I (MHC class I})MHC II (Major histocompatibility complex class II receptor)

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