N-Hydroxy-N-Isopropyloxamic Acid

N-Hydroxy-N-Isopropyloxamic Acid is a small molecule belonging to the class of hydroxamic acids. It is primarily studied as an experimental compound and has not been approved for clinical use. The compound acts as a potent inhibitor of certain enzymes involved in amino acid biosynthesis—most notably ketol-acid reductoisomerase—which plays a crucial role in the biosynthesis of branched-chain amino acids in bacteria. By binding to the active site of this enzyme and forming a stable complex, it disrupts bacterial growth by inhibiting essential metabolic pathways. This mechanism makes it valuable for research into antibacterial agents and enzyme inhibition[1][2]. The compound is solid at room temperature with good water solubility and has been explored mainly within medicinal chemistry and drug development contexts[1][6].

Other names

N-hydroxy-N-isopropyloxamate2-[hydroxy(propan-2-yl)amino]-2-oxoacetic acid[hydroxy(propan-2-yl)amino](oxo)acetic acidAcetic acid, 2-[hydroxy(1-methylethyl)amino]-2-oxo-, potassium salt (1:1)HIO