Drug intelligence / Profile preview

N-nonyldeoxynojirimycin

Development stage
Unknown
Modality
Small Molecules
Administration
Oral
01

Overview

N-nonyldeoxynojirimycin (NN-DNJ) is a synthetic small molecule and a derivative of deoxynojirimycin in which the amino hydrogen is replaced by a nonyl group. It acts as an inhibitor of glucosidase enzymes, specifically targeting acid α-glucosidase and α-1,6-glucosidase. By inhibiting these enzymes, NN-DNJ disrupts carbohydrate metabolism pathways and leads to increased glycogen levels in hepatic and muscle tissues. The compound demonstrates high intestinal absorption but limited blood-brain barrier penetration. It is not significantly metabolized by cytochrome P450 enzymes[2][6].

Other names
N-nonyl-1-deoxynojirimycinN-nonyl1-deoxynojirimycinN-nonyl 1-deoxynojirimycinN-nonyldeoxynojirimycinN-n-nonyl-deoxy-nojirimycinN-n-nonyl-deoxynojirimycin
02

Targets

GAA (Lysosomal acid alpha-glucosidase)AGL (Glycogen debranching enzyme)

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