n-phenyl pyrazoline 5

N-phenyl pyrazoline 5 is a **synthetic small molecule** evaluated for anticancer activity, notably in cervical cancer. It was synthesized via cyclocondensation of chalcone derivatives and phenylhydrazine. In vitro, n-phenyl pyrazoline 5 shows potent cytotoxicity against HeLa (cervical cancer) cells, with an IC50 of about 4.7 µM, inhibiting cell viability, proliferation, migration, and cancer stem cell-like phenotypes. Mechanistically, it acts as an **epidermal growth factor receptor (EGFR) inhibitor**, with molecular docking and protein studies confirming EGFR (and to a lesser extent ERBB2) as the primary target. This leads to suppression of key oncogenic processes including metastasis and stemness, and sensitization of cancer stem cells to chemotherapy. Characterization was performed by NMR, GC-MS, and FTIR, and the primary research has been conducted in vitro, without evidence of clinical development[1][3].

Other names

P5P-5P 5pyrazoline 5pyrazoline5pyrazoline-5