Drug intelligence / Profile preview

N0728

Development stage
Phase 3
Lead developer
Eurofarma
Modality
Small Molecules
Administration
Oral
01

Overview

**N0728** is Eurofarma's oral fixed-dose combination of solifenacin and tamsulosin under Phase 3 evaluation for moderate-to-severe lower urinary tract symptoms associated with benign prostatic hyperplasia. Solifenacin is an antimuscarinic agent that reduces detrusor overactivity and storage symptoms, while tamsulosin is an alpha-1 adrenergic receptor antagonist that relaxes smooth muscle in the prostate and bladder neck to improve urinary flow and voiding symptoms. The BENIPRO trial is evaluating N0728 against the established solifenacin/tamsulosin product Vesomni. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT06546735))

Other names
solifenacin + tamsulosin
02

Targets

ADRA1A (α1A)ADRA1D (α1D)CHRM3 (M3)

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