N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane

N1,N14-Bis((S-Methyl)Isothioureido)Tetradecane is a synthetic small molecule compound with the molecular formula C18H38N4S2 and a molecular weight of approximately 374.7 g/mol. It belongs to the class of isothiourea derivatives and has been studied as an inhibitor of nitric oxide synthase (NOS), particularly targeting the heme domain of endothelial NOS. Structural studies have shown that bulky bis(isothiourea)s like this compound can bind to the active site pocket of NOS enzymes, providing insights for isoform-selective inhibitor design. Its primary mechanism involves inhibition of nitric oxide synthase activity, which may be relevant in modulating physiological and pathological NO production[7][9].

Other names

(E)-N'-(14-((E)-N'-(amino(methylsulfanyl)methylidene)amino)tetradecyl)(methylsulfanyl)methanimidamide(E)-N'-{14-[(E)-N'-[amino(methylsulfanyl)methylidene]amino]tetradecyl}(methylsulfanyl)methanimidamidedimethyl N',N'''-tetradecane-1,14-diylbis(imidothiocarbamate)dimethyl N',N'''-1,14-tetradecanediylbiscarbamimidothioate