N20 blocking peptide

The **N20 blocking peptide** is a synthetic peptide that specifically blocks the binding between **CRIPTO** (also known as TDGF1) and **GRP78** (Glucose-Regulated Protein 78, also known as HSPA5), thereby inhibiting CRIPTO/GRP78-dependent signaling. This pathway is implicated in promoting aggressive tumor phenotypes and chemoresistance in hepatocellular carcinoma and potentially other cancers. By blocking CRIPTO/GRP78 interaction, the N20 peptide reduces downstream AKT signaling and enhances tumor responsiveness to agents such as sorafenib. The peptide is used in research settings to evaluate CRIPTO signaling dependency and therapeutic modulation in cancer models[2].

Other names

GRP78 N20 blocking peptideGRP-78 N20 blocking peptideGRP 78 N20 blocking peptidesc1050Psc-1050Psc 1050P