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N2B-2502
- Development stage
- Preclinical
- Lead developer
- Emory University
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
N2B-2502 (also known as [18F]N2B-2502 or [18F]1) is a novel fluorine-18 labeled imidazopyridinone analog developed by researchers at Emory University as a positron emission tomography (PET) radioligand. It selectively targets the glutamate N-methyl-D-aspartate (NMDA) receptor subunit epsilon-2 (GluN2B), which plays a critical role in regulating receptor function and synaptic plasticity. Dysregulation of GluN2B-containing NMDA receptors is implicated in various neurological and neurodegenerative disorders. In preclinical rodent models, [18F]N2B-2502 demonstrated robust specific binding in GluN2B-enriched brain regions (such as the cortex, striatum, and thalamus) and exhibited good metabolic stability, making it a promising non-invasive imaging tool to study GluN2B distribution and pathology in vivo.
- Other names
- [18F]1[18F]N2B-2502compound 1compound1compound-1
02
Targets
GRIN2B (N-methyl-D-aspartate Receptor Subunit Combination: NR1a/NR2B)
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