n6-cyclopentyladenosine

N6-cyclopentyladenosine is a **selective adenosine A1 receptor agonist** used primarily as a pharmacological tool in scientific research. It displays high affinity for the adenosine A1 receptor (Ki = 2.3 nM), with much lower affinity for A2A (Ki = 790 nM) and A3 (Ki = 43 nM) receptors, and very low activity at A2B (EC50 = 18600 nM)[1][16]. Its main effects are **cardiovascular—bradycardia and hypotension—via adenosine A1 receptor activation**; it also produces behavioral and central nervous effects, such as memory impairment and modulation of seizure thresholds in animal models[3][7][12]. It is **not approved for clinical or therapeutic use**, but widely used as a reference agonist for adenosine A1 receptor function in cardiovascular, neurological, and biochemical studies.

Other names

cyclopentyladenosineN-cyclopentyladenosineN(6)-cyclopentyladenosineadenosine N-cyclopentyl-N(sup 6)-cyclopentyladenosine