Na-AuPT

Na-AuPT is a **novel, water-soluble gold(I) complex** developed as a **metal-based proteasome inhibitor** for anticancer therapy. It inhibits both 20S proteasome catalytic subunits and 19S proteasome-associated deubiquitinases (DUBs), thereby **blocking the ubiquitin-proteasome system (UPS)** which is essential for protein degradation in cells. Na-AuPT exerts significant in vitro and in vivo antitumor activity by inducing cell death and apoptosis in a variety of cancer cell lines, and in animal models this compound demonstrated tumor growth inhibition. Mechanistic studies show accumulation of ubiquitinated proteins and activation of apoptosis-related proteins (cleaved caspase 3, Bax). Na-AuPT is a preclinical candidate and, to date, has not been approved or included in advanced clinical trials for human therapy.

Other names

sodium gold(I) complex Na-AuPT