nabumetone

Nabumetone is a nonsteroidal anti-inflammatory drug (NSAID) of the naphthylalkanone class, primarily indicated for the symptomatic relief of osteoarthritis and rheumatoid arthritis. It is a non-acidic prodrug that undergoes extensive hepatic metabolism to form its active metabolite, 6-methoxy-2-naphthylacetic acid (6-MNA). This metabolite acts as a potent inhibitor of cyclooxygenase (COX) enzymes, with some evidence suggesting a degree of partial selectivity for COX-2. Nabumetone is distinguished by its relatively low incidence of gastrointestinal side effects compared to traditional acidic NSAIDs, likely due to its non-acidic nature and the fact that its active form is generated post-absorption. It is typically administered once daily and has been evaluated for its safety profile in elderly patients and its minimal impact on platelet aggregation.

Brand names

RelafenCenatone

Other names

nabumetone