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nadorameran
- Development stage
- Phase 1
- Lead developer
- BioNTech
- Modality
- Vaccines & Immunotherapeutics, mRNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
- Administration
- Intradermal, Intramuscular
01
Overview
**Nadorameran** is an investigational mRNA-based prophylactic vaccine developed by CureVac using proprietary RNActive® technology. It encodes the rabies virus glycoprotein (RABV-G), instructing host cells to produce this antigen to elicit neutralizing antibodies against rabies virus. As the first mRNA drug substance assigned an International Nonproprietary Name (INN) by WHO, it demonstrated safety, tolerability, and immunogenicity in a phase I trial (NCT02241135), inducing boostable functional antibodies via intradermal or intramuscular needle-free injection, marking a proof-of-concept for mRNA vaccines in humans.[1][3][7][13]
- Other names
- CV7201 mRNACV-7201 mRNACV 7201 mRNARNActive rabies vaccine
02
Targets
RABV-G (Rabies virus glycoprotein)
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