nadroparin

Nadroparin is a low molecular weight heparin (LMWH) anticoagulant derived from porcine sources. It is used for the prevention and treatment of thromboembolic disorders, including deep vein thrombosis (DVT), pulmonary embolism, unstable angina, and non-Q-wave myocardial infarction. Nadroparin is also indicated to prevent clotting during hemodialysis and in patients undergoing general or orthopedic surgery at risk of thromboembolism. Its mechanism of action involves high-affinity binding to antithrombin III (ATIII), which accelerates the inhibition of factor Xa and, to a lesser extent, factor IIa (thrombin), thereby inhibiting the coagulation cascade. Additional antithrombotic effects include stimulation of tissue factor pathway inhibitor release and activation of fibrinolysis via tissue plasminogen activator from endothelial cells. Developed and manufactured by Sanofi.

Brand names

Fraxiparine

Other names

nadroparin calcium