nafenopin

Nafenopin is a synthetic aryloxyisobutyric acid derivative investigated as a **hypolipidemic agent** (substance used to lower lipid levels in the blood, particularly triglycerides)[5]. Its primary mechanism of action is the activation of **peroxisome proliferator-activated receptor alpha (PPARα)**, a nuclear receptor that regulates genes involved in lipid metabolism and peroxisome proliferation. This leads to increased fatty acid β-oxidation in the liver, reduction of triglycerides and cholesterol, but also to peroxisome proliferation, which has been associated with liver toxicity and increased risk of liver tumors in preclinical studies. Nafenopin was never marketed because of its carcinogenic potential demonstrated in animal toxicology studies[5].

Brand names

Melipan

Other names

2-methyl-2-(4-tetralin-1-ylphenoxy)propionic acid2-methyl-2-[4-(1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]propanoic acidnafenopin USP/EP/BP