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NAIN02 is a preclinical-stage small molecule developed by Hangzhou Nain Biotech that targets Organic Cation Transporter 3 (OCT3), also known as Solute Carrier Family 22 Member 3 (SLC22A3). The drug is being developed for the treatment of solid tumors. Hangzhou Nain Biotech's development platform focuses on addressing drug resistance by targeting regulated cell death (RCD) and cancer stem cells (CSC). OCT3 is a transporter involved in the uptake and efflux of various organic cations, including neurotransmitters and certain chemotherapeutic agents; its modulation is intended to influence the tumor microenvironment or overcome resistance mechanisms in solid malignancies.
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