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NAL8812 is a transdermal patch formulation of donepezil, an acetylcholinesterase inhibitor, being developed by NAL Pharmaceutical Group for the treatment of Alzheimer's disease. The patch is designed for 3-day (twice-weekly) administration, utilizing NAL's proprietary transdermal delivery technology to provide sustained release of the drug. By inhibiting acetylcholinesterase, it increases the concentration of acetylcholine in the brain, which is intended to improve cognitive function in patients with Alzheimer's. The transdermal route aims to reduce gastrointestinal side effects and improve patient compliance compared to oral formulations.
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