nalmefene ProNeura

**Nalmefene ProNeura** is an investigational subdermal implant formulation of nalmefene, an opioid system modulator, developed by Titan Pharmaceuticals using their ProNeura technology for long-term continuous delivery over six months or longer. Nalmefene acts as an antagonist at mu- and delta-opioid receptors and a partial agonist at the kappa-opioid receptor, potentially reducing alcohol consumption by modulating cortico-mesolimbic functions and restoring dysregulations in opioid systems, while also reversing opioid effects like respiratory depression. The implant aims to provide steady nalmefene release for treating alcohol dependence or opioid use disorder, addressing limitations of short-acting oral or injectable forms.[11][16]

Other names

nalmefene implant