naltrexone + antiretrovirals

This is a combination therapy involving naltrexone, an opioid receptor antagonist, and antiretroviral drugs used for the treatment of HIV infection. Naltrexone is primarily indicated for opioid use disorder (OUD) and alcohol use disorder (AUD), acting as a competitive antagonist at mu, kappa, and delta opioid receptors to block the effects of opioids and reduce cravings for alcohol[1][6]. Antiretrovirals are a class of medications that inhibit various stages of the HIV life cycle to suppress viral replication[9]. The combination is not available as a fixed-dose product but refers to concurrent administration in clinical practice—particularly in people with HIV who also have substance use disorders. Studies indicate that extended-release naltrexone can be safely co-administered with antiretroviral therapy (ART) without significant pharmacokinetic interactions or loss of ART efficacy[2][8]. This approach may improve engagement in care and viral suppression among people living with HIV who have OUD or AUD[4].