Drug intelligence / Profile preview

naltrexone + nicotine

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral, Transdermal
01

Overview

Naltrexone + nicotine is a combination therapy used for smoking cessation. Naltrexone is an opiate blocker that works by inhibiting the chemical signals within the brain that convey pleasure when people use drugs such as nicotine. When combined with nicotine replacement therapy (typically delivered via patches), this combination helps reduce cigarette cravings and lessens withdrawal discomfort. Research has shown this combination to be particularly effective for women, boosting smoking cessation rates by almost 50 percent when assessed after eight weeks of treatment. The combination also helps prevent the weight gain commonly associated with smoking cessation.

02

Targets

α4β2 nAChR (Nicotinic acetylcholine receptor alpha4 beta2 subtype)CHRNA7 (α7 nicotinic receptor)DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)

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