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naltrexone transdermal patch (Libero Pharma Limited)
- Development stage
- Preclinical
- Lead developer
- Libero Pharma
- Modality
- Small Molecules
- Administration
- Transdermal
01
Overview
Libero Pharma is developing a transdermal naltrexone patch for the treatment of Opioid Use Disorder (OUD), Alcohol Use Disorder (AUD), Fibromyalgia, and Crohn's disease. Naltrexone is a small molecule opioid receptor antagonist that primarily blocks μ-opioid receptors to reduce opioid effects and cravings. This transdermal delivery system is designed to provide a more consistent release, avoiding the first-pass metabolism and hepatotoxicity associated with oral naltrexone, while potentially improving patient compliance compared to intramuscular depot injections. Libero Pharma, founded in 2018 and based in Edinburgh, Scotland, focuses on optimized transdermal delivery to address unmet medical needs in addiction and inflammation.
- Other names
- Transdermal Naltrexone patchNaltrexone (transdermal)
02
Targets
DOR (Opioid Receptor Delta 1)KOR (Kappa opioid receptor)MOR (Mu opioid receptor)
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