Nanchang Univ. HDAC1 compound 9d

Nanchang Univ. HDAC1 compound 9d: sourced facts only. name: "The activities in vitro showed compound 9d exhibited 12 folds more potent than MS-275 against HDAC1 isoform and showed excellent inhibitory activity on cancer cells, including HCT-116, MDA-MB-231, K562 cell lines." [PMID:35041998]; target: "The activities in vitro showed compound 9d exhibited 12 folds more potent than MS-275 against HDAC1 isoform and showed excellent inhibitory activity on cancer cells, including HCT-116, MDA-MB-231, K562 cell lines." [PMID:35041998]; developer: "School of Pharmaceutical Sciences, Nanchang University, Nanchang 330006, China." [PMID:35041998]; stage: "Further biological validation demonstrated that 9d prevented cell transition from G1 phase to S phase by reducing Cyclin D1, CDK2 and lifting p21, induced early apoptosis by upregulating BAX and downregulating Bcl-2 in HCT-116 cells." [PMID:35041998]