nano-crystalline hydroxyapatite silica gel

Nano-crystalline hydroxyapatite silica gel is a synthetic bone graft substitute material used in medical applications, particularly in bone regeneration and dental procedures. It consists of nanocrystalline hydroxyapatite (NHA) components embedded in a highly porous silica gel matrix. ## Composition and Structure The material features nanocrystalline hydroxyapatite particles (typically around 35 nm in size) embedded within a silica gel matrix. This combination creates a highly porous structure with nano, micro, and macro pores that enhance the material's overall porosity up to 60%. The nanostructure of the hydroxyapatite platelets is designed to mimic the natural hydroxyapatite found in bone tissue. Unlike traditional synthetic hydroxyapatite scaffolds, the hydroxyapatite in this material is precipitated and unsintered to preserve its highly porous and permeable nanoarchitecture and degradation properties. This specific manufacturing approach ensures that the material closely resembles natural bone structure. ## Mechanism of Action The silica gel component stimulates the formation of collagen and bone tissue. When implanted, the material undergoes a biological transformation where the silica gel matrix is exchanged for autologous proteins within approximately 10 days. This exchange, combined with the nanostructured hydroxyapatite, creates a compound very similar to skeletal bone, promoting effective bone remodeling. The high inner surface area of the material is key to its biological efficiency, as it increases interaction with serum, enhances autologous protein enrichment, and facilitates the formation of an extracellular matrix to initiate bone healing. ## Clinical Applications This bone graft substitute is used in various clinical applications: - Socket preservation after tooth extraction - Filling of alveolar cavities to stabilize bony alveolar ridge - Alveolar ridge reconstruction - Sinus lift and/or sinus floor elevation procedures - Augmentation of alveolar ridge defects - Treatment of peri-implant lesions - Management of periodontal intrabony defects - Filling bony voids or gaps of the skeletal system (extremities, posterolateral spine, and pelvis) ## Clinical Benefits The material offers several advantages in clinical settings: - Comparable healing rate to autograft without the costs and complications of harvesting - Rapid absorption and reliable bone fusion - Early osteogenesis - Osteoconductive and biomimetic properties - Integration into the host's physiological bone turnover at an early stage - Prevention of bone atrophy after tooth extraction - Improvement of wound healing In clinical studies, it has demonstrated rapid and reliable fusion and healing rates comparable to autologous bone grafting, with low complication rates and high union rates. The material is commercially available in various forms and sizes, including preloaded applicators ranging from 0.25mL to 10mL, making it versatile for different clinical scenarios.

Brand names

Cerabone

Other names

NanoBone Synthetic Bone Graft SubstituteNanoBone SBX PuttyNanoBone QD