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nano-hyaluronic acid

Development stage: Phase 2
Lead developer: Cairo University
Modality: Nanoparticles → Drug Delivery Systems
Administration: Topical

Overview

Nano-hyaluronic acid (nano-HyA) is a specialized formulation of hyaluronic acid, a naturally occurring glycosaminoglycan, engineered into nanoparticles to improve tissue penetration and biological efficacy. Developed for use in periodontology, specifically as an adjunct to minimally invasive non-surgical techniques (MINST), it is applied as a gel into deep intrabony defects. The drug works by modulating the inflammatory response, promoting soft tissue healing, and stimulating the regeneration of periodontal tissues through interactions with receptors like CD44. Cairo University is evaluating its effectiveness in treating Stage II and III periodontitis.

Other names: nano-hyaluronic acid gel

Targets

LYVE1 (Lymphatic vessel endothelial hyaluronic acid receptor 1)RHAMM (Hyaluronan-mediated motility receptor)CD44 (CD44 antigen)

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