nano-luteolin

Nano-luteolin refers to a class of nanotechnology-based formulations in which the natural flavonoid luteolin is encapsulated or incorporated into nanoscale carriers such as polymeric nanoparticles, nanovesicles, micelles, or other delivery systems. These nanoformulations are designed to overcome the poor water solubility, low bioavailability, and rapid metabolism of free luteolin. By using nanocarriers (e.g., polymers like PEG or phospholipids), nano-luteolin enhances the solubility and stability of luteolin in biological environments and enables targeted delivery to tissues. Mechanistically, these formulations retain the pharmacological activities of luteolin—including anti-inflammatory, antioxidant, anticancer (notably against lung cancer), antibacterial (including activity against bacterial prostatitis), neuroprotective effects—by modulating multiple molecular pathways such as inhibition of PI3K/Akt-mediated NF-κB and MAPK signaling pathways. Nanoformulations have demonstrated improved therapeutic efficacy with reduced cytotoxicity compared to free luteolin in preclinical models[1][2][3][4][5][6].

Other names

polymer-encapsulated luteolin nanoparticlepolyluteolin nanoparticlesluteolin-loaded nanovesiclesLT-NVs