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Nano-QUT
- Development stage
- Preclinical
- Lead developer
- Cairo University
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Intratumoral, Intravenous
01
Overview
Nano-QUT is a nanoparticle-encapsulated formulation of the bioactive flavonoid quercetin, utilizing a poly(lactic-co-glycolic acid)-poly(ethylene glycol) (PLGA-PEG) polymer matrix for drug delivery. Quercetin is a naturally occurring polyphenolic compound known for its antioxidant, anti-inflammatory, and antineoplastic properties; however, its clinical application is often hindered by poor aqueous solubility, low bioavailability, and rapid systemic clearance. Nano-QUT is designed to overcome these limitations by providing a sustained-release delivery system that enhances cellular uptake and specific tissue distribution. Developed for the treatment of oral malignancies such as tongue squamous cell carcinoma (TSCC), Nano-QUT aims to improve the induction of apoptosis and inhibition of tumor cell proliferation compared to free quercetin by modulating key oncogenic signaling pathways.
- Other names
- nano-quercetinquercetin-loaded PLGA-PEG nanoparticlesPLGA-PEG-encapsulated quercetin
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