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nanocarrier-enhanced alpha hydroxy acid
- Development stage
- Unknown
- Lead developer
- Al-Azhar University
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Topical
01
Overview
Nanocarrier-enhanced alpha hydroxy acid is an investigational topical formulation designed as a steroid-sparing strategy for the treatment of plaque psoriasis [2894]. Developed by researchers at Al-Azhar University, this formulation utilizes nanotechnology to improve the epidermal penetration of alpha hydroxy acids (AHAs) through hyperkeratotic psoriatic plaques [2894]. By enhancing delivery, the nanocarrier preserves the keratolytic and anti-inflammatory potential of AHAs while minimizing local irritation and avoiding the side effects associated with prolonged corticosteroid use [2894]. In a double-blind comparative clinical study, the formulation demonstrated clinically meaningful improvements in the Psoriasis Area and Severity Index (PASI) and Dermatology Life Quality Index (DLQI) over conventional AHA and placebo, representing a promising topical option for mild-to-moderate plaque psoriasis [2894].
- Other names
- nanocarrier-enhanced AHAnanocarrier-enhanced alpha hydroxy acid formulation
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