Drug intelligence / Profile preview

nanocelle insulin

Development stage
Discontinued
Lead developer
Medlab Clinical
Modality
Nanoparticles → Drug Delivery Systems, Peptides
Administration
Buccal, Intranasal
01

Overview

Nanocelle Insulin is an investigational reformulated insulin therapy developed by Medlab Clinical. It utilizes Medlab's proprietary NanoCelle® delivery platform, which encapsulates insulin into nano-sized micelles (nanoscopic fat-soluble core surrounded by a water-soluble outer layer) to enable non-invasive delivery across the oro-buccal or nasal mucosa. This delivery system is designed to bypass gastrointestinal degradation and avoid subcutaneous injections, mimicking the pharmacokinetic profile of naturally produced insulin with a faster onset of action. Clinical development has included a withdrawn Phase 0 safety and pharmacokinetics study of an oro-buccal spray formulation in healthy volunteers, as well as preclinical exploration of an intranasal variant (MC-1006) for blood glucose control and cognitive deficits.

Other names
NanoCelle InsulinNanoCelle® InsulinNanoCelle™ insulin formulationinsulin oro-buccal sprayNanoCelle Intranasal Insulin
02

Targets

INSR (Insulin receptor)IGF-1R (Insulin-like growth factor 1 receptor)

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