nanoceria

Nanoceria refers to **cerium oxide nanoparticles (CeO2)**. These nanoparticles possess unique redox properties enabling reversible cycling between Ce^3+^ and Ce^4+^ oxidation states, conferring **antioxidant and immunomodulatory activity**. Nanoceria acts primarily by **scavenging reactive oxygen species (ROS)**—especially at high concentrations—thereby protecting tissues from oxidative stress and inflammation[1][2][4][6]. They have demonstrated efficacy in preclinical models of **cardiac disease, diabetes, retinal disease, gastrointestinal inflammation, liver inflammation, cancer, neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, traumatic brain injury, ischemia), sepsis, age-related degeneration, and metabolic syndrome**[1][3][4][6][9][10]. In cancer models, nanoceria can act as a **pro-oxidant under hypoxic tumor microenvironments**, inhibiting hypoxia-inducible factor 1-alpha (HIF-1α) and promoting cytotoxic ROS generation to inhibit tumor growth, metastasis, and drug resistance[3]. Nanoceria can also serve as a carrier for drug delivery, improving drug efficacy and selectivity[9][5][8]. The material exhibits low toxicity to normal tissues, is slowly excreted, and displays a favorable pharmacological profile[1][5][8].

Brand names

nanoceria

Other names

cerium oxide nanoparticlesCeO2 nanoparticlesCeO-2 nanoparticlesCeO 2 nanoparticlesnanoceria particles