nanocrystal megestrol acetate

Nanocrystal megestrol acetate is an advanced oral formulation of **megestrol acetate** engineered using nanocrystal technology to enhance its bioavailability, especially under fasting conditions. Traditional micronized megestrol acetate oral suspensions, such as Megace OS, have limited absorption when taken without food. The nanocrystal formulation overcomes this by allowing for rapid and efficient absorption, leading to significantly higher systemic drug exposure even in the fasting state. Megestrol acetate is a synthetic progestin used primarily to stimulate appetite and promote weight gain in patients with cancer-associated anorexia, cachexia, or wasting syndromes. It also possesses antineoplastic effects and has been used in therapy for certain cancers such as breast and endometrial cancer. The predominant mechanism of action is as an agonist at the progesterone receptor. The nanocrystal formulation does not alter the pharmacodynamics of megestrol acetate but significantly optimizes its pharmacokinetic profile[1][2][4][6].

Other names

nanoparticulate megestrol acetatenano-crystalline megestrol acetatenanocrystal formulation of megestrol acetate