Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
nanocrystalline megestrol acetate + ondansetron
- Development stage
- Unknown
- Lead developer
- AIPING ZHOU
- Modality
- Small Molecules
- Administration
- Oral, Intravenous
01
Overview
A combination therapy consisting of a nanocrystalline formulation of megestrol acetate and the 5-HT3 receptor antagonist ondansetron. Megestrol acetate is a synthetic progestin that, in its nanocrystalline form, exhibits improved bioavailability and is traditionally used to treat anorexia and cachexia. In this clinical study led by Aiping Zhou, it is being evaluated for the prevention of chemotherapy-induced nausea and vomiting (CINV) in patients with gastric adenocarcinoma receiving moderately emetogenic chemotherapy (CAPOX plus PD-1/PD-L1 inhibitors). Ondansetron is a standard antiemetic that works by blocking serotonin receptors in the gastrointestinal tract and the central nervous system to inhibit the vomiting reflex.
- Other names
- nanocrystalline megestrol acetate combined with ondansetron
02
Targets
HTR3A (5-hydroxytryptamine receptor 3A)PR (Progesterone receptor)
Beyond the preview
Go deeper on nanocrystalline megestrol acetate + ondansetron.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on nanocrystalline megestrol acetate + ondansetron.