nanocurcumin

Nanocurcumin is an advanced nanoparticle formulation of curcumin, the active polyphenol derived from turmeric (*Curcuma longa*). It is specifically designed to overcome the significant pharmacological hurdles of standard curcumin, including poor aqueous solubility, rapid systemic clearance, and low bioavailability. By encapsulating curcumin within nanomicelles, the formulation achieves markedly higher absorption and stability. In the context of relapsing-remitting multiple sclerosis (RRMS), nanocurcumin is investigated for its potent anti-inflammatory and immunomodulatory properties. Its mechanism of action involves the inhibition of key pro-inflammatory signaling pathways, specifically Nuclear factor kappa B (NF-κB) and Signal transducer and activator of transcription 3 (STAT3). This inhibition leads to a favorable shift in the immune profile, characterized by a reduction in pro-inflammatory Th17 cells and an increase in anti-inflammatory regulatory T cells (Tregs), which may help mitigate the autoimmune response in MS patients.

Other names

curcumin nanomicellesnanoparticle curcuminnano-curcumin