Drug intelligence / Profile preview

Nanoimod

Development stage
Preclinical
Lead developer
Lidds
Modality
MicroRNA (miRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Vaccines & Immunotherapeutics, Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Small Interfering RNA (siRNA) → Small RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics
Administration
Intratumoral
01

Overview

Nanoimod is a cancer immunotherapy developed by LIDDS AB, consisting of the Toll-like receptor 9 (TLR9) agonist agatolimod formulated with the proprietary NanoZolid drug delivery technology. NanoZolid enables the local, controlled, and sustained release of agatolimod from an intratumoral depot for at least six weeks, minimizing the need for repeated injections and reducing systemic exposure. By activating TLR9, the drug stimulates both innate and adaptive anti-tumor immune responses. It is currently in preclinical development, with plans for Phase Ib clinical studies in multiple cancer indications, including head and neck cancer, prostate cancer, sarcomas, and lymphomas, both as a monotherapy and in combination with checkpoint inhibitors.

Other names
NanoZolid-formulated agatolimodagatolimod
02

Targets

TLR9 (Toll-like receptor 9)

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