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NanoStat
- Development stage
- Unknown
- Lead developer
- Medlab Group
- Modality
- Small Molecules, Nanoparticles → Drug Delivery Systems
- Administration
- Sublingual
01
Overview
NanoStat is a cardiovascular medication developed by Medlab Clinical (ASX: MDC) that utilizes the company's proprietary NanoCelle delivery technology to administer atorvastatin. Atorvastatin is a small molecule statin that functions as a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in the hepatic cholesterol synthesis pathway. NanoStat is formulated as an orobuccal spray, which allows for the delivery of atorvastatin in a 'free' form by cleaving the calcium salt pre-absorption. This delivery mechanism is designed to bypass first-pass metabolism, with clinical data indicating that a 1 mg spray dose can achieve higher free blood levels and improved metabolic functioning compared to a standard 20 mg oral tablet.
- Brand names
- NanoStat
02
Targets
HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)
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