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NANOVAE
- Development stage
- Phase 2
- Lead developer
- Nova Vita Laboratories
- Administration
- Intraarticular
01
Overview
NANOVAE is an allogenic human amniotic fluid-derived biologic product developed by Novavita Laboratory. It is currently being evaluated in Phase I/II clinical trials for the treatment of knee osteoarthritis (KOA). The therapeutic rationale is based on the regenerative and anti-inflammatory properties of amniotic fluid, which contains a complex mixture of cytokines, growth factors, and microRNAs (miRNAs). These components, such as miR-130, miR-149, and miR-320c, are thought to modulate the inflammatory response by regulating pro-inflammatory cytokines (IL-1, IL-6, TNF-α) and inhibiting matrix-degrading enzymes like MMP-13 and ADAMTS5. By targeting these pathways, NANOVAE aims to alleviate pain, reduce joint stiffness, and potentially enhance chondrogenesis in patients with degenerative joint disease.
- Brand names
- NANOVAE
- Other names
- Allogenic Human Amniotic Fluid
02
Targets
IL-6 (Interleukin 6)MMP13 (Matrix metalloproteinase-13)ADAMTS5 (A disintegrin and metalloproteinase with thrombospondin motifs 5)TNFA (Tumor necrosis factor alpha (soluble))IL1A (Interleukin 1 alpha)
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