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NANT NHL Vaccine
- Development stage
- Discontinued
- Lead developer
- ImmunityBio
- Modality
- Small Molecules, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Monoclonal Antibodies → Antibody-Based Therapeutics, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Vaccines & Immunotherapeutics
- Administration
- Subcutaneous, Intravenous
01
Overview
**NANT NHL Vaccine** is an investigational, sponsor-specific multimodal cancer-immunotherapy regimen evaluated as QUILT-3.052 for relapsed CD20-positive non-Hodgkin lymphoma after rituximab therapy. Rather than a single molecular vaccine, it is a protocol-level combination that can incorporate metronomic chemotherapy, tumor-antigen vaccination, immune-cell therapy, cytokine stimulation, targeted antibodies, and radiotherapy. The registered study was a Phase 1b/2 trial and is listed as withdrawn; therefore, this program should not be treated as an approved or currently established lymphoma vaccine. ([clinicaltrials.gov](https://clinicaltrials.gov/study/NCT03169790))
- Other names
- NANT Non-Hodgkin Lymphoma Vaccine
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)
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