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NANT NSCLC Vaccine
- Development stage
- Discontinued
- Lead developer
- ImmunityBio
- Modality
- Small Molecules, CAR-NK Cells → Other Engineered Cells → Adoptive Cell Transfer → Cell Therapies, Peptides, Monoclonal Antibodies → Antibody-Based Therapeutics, Lymphokine-Activated Killer Cells → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies, Cytokines & Interferons → Recombinant Proteins and Enzymes, Vaccines & Immunotherapeutics
- Administration
- Intravenous, Subcutaneous, Oral, Intramuscular
01
Overview
**NANT NSCLC Vaccine** was an investigational, multi-agent combination-immunotherapy protocol for non-small cell lung cancer that had progressed after PD-1 or PD-L1 inhibitor treatment. The QUILT-3.044 Phase 1b/2 study combined metronomic chemotherapy and stereotactic radiation with checkpoint inhibitors, anti-VEGF therapy, tumor-antigen vaccines, the IL-15 superagonist ALT-803, and haNK natural-killer cells. Vaccine constituents included adenoviral vectors directed against CEA, HER2, MUC1, and brachyury and yeast-based vaccines directed against mutant RAS, CEA, and brachyury. The registered trial was withdrawn and enrolled zero participants. ([cdek.pharmacy.purdue.edu](https://cdek.pharmacy.purdue.edu/trial/NCT03169738/))
- Other names
- NANT Non-small Cell Lung Cancer VaccineQUILT-3.044QUILT3.044QUILT 3.044
02
Targets
IL-15R (Interleukin 15 receptor alpha/interleukin 15 complex)
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