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Nant-T-cell

Development stage: Unknown
Lead developer: ImmunityBio
Modality: CAR-T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, TCR-Engineered T Cells → Engineered T Cells → Adoptive Cell Transfer → Cell Therapies, Tumor-Infiltrating Lymphocytes (TILs) → Native Immune Cells → Adoptive Cell Transfer → Cell Therapies
Administration: Intravenous

Overview

**Nant-T-cell (NTD-T)** is an autologous T-cell therapy developed by ImmunityBio (formerly NantCell). It consists of patient-derived T cells that are expanded ex vivo and re-infused into the patient to bolster the immune response against malignant cells. NTD-T is typically administered as part of a combination regimen (the "Nant" platform) that includes other immunotherapies such as N-803 (an IL-15 superagonist), natural killer (NK) cell therapies (e.g., haNK), and targeted agents. The therapy is designed to leverage the patient's own adaptive immune system to recognize and eliminate tumor cells, particularly in the context of solid tumors like triple-negative breast cancer and Merkel cell carcinoma.

Other names: Autologous T-cells (NTD-T)

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