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Naohuan Dan
- Development stage
- Unknown
- Lead developer
- Qingdao Third People's Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Naohuan Dan is a Traditional Chinese Medicine (TCM) formulation traditionally used in China for the treatment of cognitive impairment and age-related memory loss, specifically those classified under the TCM syndromes of kidney deficiency and phlegm stasis. The formula typically comprises several herbal ingredients, including *Panax ginseng*, *Acorus tatarinowii* (Shichangpu), *Polygala tenuifolia* (Yuanzhi), and *Salvia miltiorrhiza* (Danshen). Its therapeutic effects are attributed to its neuroprotective and anti-inflammatory properties; it is reported to reduce levels of neuron-specific enolase (NSE), a biomarker of neuronal damage, and decrease pro-inflammatory cytokines such as TNF-alpha and IL-6. Clinically, it has been studied for its ability to improve cognitive scores (MMSE and MoCA) and daily living activities in patients with Mild Cognitive Impairment (MCI).
- Brand names
- Naohuan Dan
- Other names
- Naohuan PillsNaohuandanNao Huan Dan
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL-6 (Interleukin 6)ENO (Alpha-enolase)
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