Drug intelligence / Profile preview

naoxintong

Development stage: Phase 4
Lead developer: Buchang Pharmaceuticals
Modality: Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration: Oral

Overview

Naoxintong (also known as Buchang Naoxintong) is a Traditional Chinese Medicine (TCM) compound capsule widely utilized for the treatment and secondary prevention of cardiovascular and cerebrovascular diseases, including coronary heart disease, myocardial infarction, and ischemic stroke. Developed and manufactured by Shaanxi Buchang Pharmaceutical, the formula consists of 16 distinct herbal and animal-derived components, such as *Astragalus membranaceus*, *Salvia miltiorrhiza*, and *Hirudo nipponica*. Its therapeutic effects are attributed to its ability to improve blood circulation, resolve blood stasis, and supplement 'Qi' according to TCM principles. Mechanistically, Naoxintong has been shown to exert anti-inflammatory, anti-platelet, and lipid-lowering activities, which contribute to the stabilization of atherosclerotic plaques and the reduction of major adverse cardiovascular events (MACE). It is frequently studied in post-PCI (percutaneous coronary intervention) patients to evaluate its impact on plaque composition and long-term clinical outcomes.

Brand names: Buchang Naoxintong
Other names: NXTBu-Yang-Huan-Wu-Tang

Targets

HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)IL-6 (Interleukin 6)F2 (Thrombin)TNFA (Tumor necrosis factor alpha (soluble))

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