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naphazoline + methylthioninium hydroxide
- Development stage
- Unknown
- Lead developer
- FRiLAB
- Modality
- Small Molecules
- Administration
- Ophthalmic
01
Overview
Collyre Bleu (also known as Collyre Bleu Laiter) is an approved ophthalmic combination drug containing naphazoline nitrate, a vasoconstrictor, and methylthioninium hydroxide (methylene blue), a mild antiseptic and optical brightener. Developed by FRiLAB, it is indicated for the temporary relief of eye redness, irritation, and noninfectious conjunctivitis. Naphazoline acts as an agonist on alpha-adrenergic receptors, causing vasoconstriction of the conjunctival blood vessels to reduce redness and congestion. Methylthioninium hydroxide provides a mild antiseptic effect and imparts a blue tint that acts as an optical brightener, visually counteracting yellow or dull tones in the sclera to make the eyes appear whiter and brighter.
- Brand names
- CentiluxCollyre BleuCollyre Bleu Laiter
- Other names
- naphazoline + methylene bluenaphazoline nitrate + methylene bluenaphazoline nitrate + methylthioninium hydroxide
02
Targets
ADRA1B (α1B)ADRA1D (α1D)ADRA2A (α2A)ADRA2B (α2B)ADRA2C (α2C)ADRA1A (α1A)
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