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naphazoline + chlorphenamine
- Development stage
- Phase 4
- Lead developer
- Qualiphar
- Modality
- Small Molecules
- Administration
- Intranasal
01
Overview
Vasocedine is a combination pharmaceutical product primarily used as a nasal decongestant and antihistamine. It contains naphazoline, a sympathomimetic amine that acts as a potent vasoconstrictor by stimulating alpha-adrenergic receptors in the nasal mucosa, thereby reducing swelling and congestion. The second component, chlorphenamine, is a first-generation antihistamine that acts as a competitive antagonist at H1 histamine receptors, helping to alleviate allergic symptoms such as sneezing and rhinorrhea. The product is commonly marketed in Belgium by Qualiphar and has been the subject of formulation research at institutions like Ghent University (Universiteit Gent), particularly regarding nasal drug delivery systems.
- Brand names
- Vasocedine
- Other names
- naphazoline nitrate + chlorphenamine maleate
02
Targets
ADRA1A (α1A)ADRA2A (α2A)HRH1 (Histamine H1 Receptor)
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