naphazoline hydrochloride

Naphazoline hydrochloride is a synthetic, direct-acting sympathomimetic amine and imidazole derivative that functions as a potent vasoconstrictor and decongestant. Originally patented in 1934 and introduced into medical use in 1942 by Ciba, the drug acts as an agonist on both alpha-1 and alpha-2 adrenergic receptors. Upon topical administration to the nasal mucosa or conjunctiva, naphazoline stimulates these receptors on vascular smooth muscle, causing rapid constriction of dilated arterioles. This localized vasoconstriction reduces blood flow, edema, and swelling, thereby providing temporary relief from nasal congestion associated with the common cold, sinusitis, and allergic rhinitis, as well as ocular redness and irritation caused by allergic conjunctivitis. It is widely available in over-the-counter (OTC) nasal sprays, nasal drops, and ophthalmic solutions.

Brand names

AlbalonClear EyesGotinalNafazolNaphconNeosoroPrivineVasocon

Other names

cloridrato de nafazolinanaphazolinenaphazoline hclnaphazoline hydrochloridenaphazoline hydrocloride