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naphazoline hydrochloride + chlorpheniramine maleate + benzalkonium bromide

Development stage
Unknown
Lead developer
SATO Pharmaceutical
Modality
Small Molecules
Administration
Intranasal
01

Overview

This combination drug is a topical nasal preparation used primarily for the symptomatic relief of nasal congestion, allergic rhinitis, and sinusitis. It contains **naphazoline hydrochloride**, a sympathomimetic amine that acts as a potent vasoconstrictor by stimulating alpha-adrenergic receptors in the nasal mucosa, thereby reducing swelling and congestion. **Chlorpheniramine maleate** is a first-generation antihistamine that antagonizes H1 receptors, effectively reducing allergic symptoms such as sneezing, itching, and rhinorrhea. **Benzalkonium bromide** serves as both an antiseptic to reduce local bacterial presence and a preservative to maintain the stability of the solution. Together, these components provide rapid relief from upper respiratory allergies and inflammatory conditions of the nasal passages.

Brand names
NazalCompound Naphazoline Hydrochloride Nasal Spray
Other names
naphazoline hydrochloride + chlorpheniramine maleate + benzalkonium bromide nasal solution
02

Targets

ADRA1A (α1A)HRH1 (Histamine H1 Receptor)

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