naproxen + peginterferon beta-1a

This is a combination of two drugs, naproxen and peginterferon beta-1a. Naproxen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins involved in inflammation, pain, and fever. Peginterferon beta-1a is a pegylated form of interferon beta-1a, an immunomodulatory agent used as a disease-modifying therapy for relapsing forms of multiple sclerosis (MS). Peginterferon beta-1a binds to type I interferon receptors on cell surfaces, leading to regulation of gene expression that upregulates anti-inflammatory cytokines and downregulates pro-inflammatory cytokines; it also inhibits migration of activated T cells across the blood–brain barrier. The combination may be used adjunctively in MS patients to manage flu-like symptoms associated with interferon therapy or as part of clinical studies evaluating their combined effects.